AB0473 EFFECT OF THYROID LESIONS ON THE COURSE OF SYSTEMIC LUPUS ERYTHEMATOSUS

Background Thyroid disease is a common complication of systemic lupus erythematosus manifesting in 30% cases due to disturbance autoimmune mechanisms. Objectives evaluating the effect thyroid lesion on course based clinical and laboratory parameters, level antibodies hormones. Methods Among 65 examined patients with SLE (63 women 2 men aged 19-65) we revealed disorder third patients. Patients were diagnosed thyroiditis 16 cases, nodular goiter (degree I II), single diffuse toxic 5 cases. The duration was years, that concomitant diseases –– 3 years. concentration hormones determined by enzyme immunoassay using immobilized thyroxine triiodothyronine. Results When gland (TG) gets involved, there pronounced discordance parameters immune hormonal status compared without complications. It found 68% had nDNA, 46% lesion, CIC - 77% 32%, respectively, IgG 54% 25%. SLICC/ACR damage index group involvement higher than second group: 4.55 3.6 points. This indicates an increase severity gland. Joint seen 79% involvement, 49% involvement. A serous membranes form pleurisy 39% 3% heart 66/24%. Lupus cell phenomenon 44 / 31%. Immunological activity prevailed combined autothyroid disease. these patients, 100% elevated thyroid-stimulating hormones, versus 15% Conclusion increases SLE, are produced actively, which indicative thyrocyte destruction blocking normal process hormone synthesis their antibodies. Disclosure Interests None declared